Audrey Perrotin -selected Publications
نویسنده
چکیده
1 La Joie, R., Landeau, B., Perrotin, A., Bejanin, A., Egret, S., Pelerin, A. et al. (2014). Intrinsic connectivity identifies the hippocampus as a main crossroad between Alzheimer's and semantic dementia-targeted networks. Neuron, 81, 1417-1428. Notes: Alzheimer's disease (AD) and semantic dementia (SD) are both characterized by severe atrophy in the hippocampus, a brain region underlying episodic memory; paradoxically, episodic memory is relatively preserved in SD. Here, we used intrinsic connectivity analyses and showed that the brain networks differentially vulnerable to each disease converge to the hippocampus in the healthy brain. As neurodegeneration is thought to spread within preexisting networks, the common hippocampal atrophy in both diseases is likely due to its location at the crossroad between both vulnerable networks. Yet, we showed that in the normal brain, these networks harbor different functions, with episodic memory relying on the AD-vulnerable network only. Overall, disease-associated cognitive deficits seem to reflect the disruption of targeted networks more than atrophy in specific brain regions: in AD, over hippocampal atrophy, episodic memory deficits are likely due to disconnection within a memory-related network
منابع مشابه
Intrinsic connectivity identifies the hippocampus as a main crossroad between Alzheimer ’ s and semantic dementia - targeted networks Running title : Brain networks , hippocampus and memory in dementia
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Relationships between years of education and gray matter volume, metabolism and functional connectivity in healthy elders
More educated elders are less susceptible to age-related or pathological cognitive changes. We aimed at providing a comprehensive contribution to the neural mechanism underlying this effect thanks to a multimodal approach. Thirty-six healthy elders were selected based on neuropsychological assessments and cerebral amyloid imaging, i.e. as presenting normal cognition and a negative florbetapir-P...
متن کاملAn ASN.1 compiler1 for embedded/space systems
George Mamais, Thanassis Tsiodras, David Lesens, Maxime Perrotin i Semantix Information Technologies, K.Tsaldari 62, Poligono 114 76, Athens, Greece {gmamais, ttsiodras}@semantix.gr ii Astrium Space Transportation. Route de Verneuil, BP 3002, F-78 133 Les Mureaux Cedex, France [email protected] iii ESTEC. Keplerlaan 1. PO Box 299, NL-2200 AG Noordwijk, The Netherlands Maxime.Perroti...
متن کاملAdded value of 18F-florbetaben amyloid PET in the diagnostic workup of most complex patients with dementia in France: A naturalistic study
INTRODUCTION Although some studies have previously addressed the clinical impact of amyloid positron emission tomography (PET), none has specifically addressed its selective and hierarchical implementation in relation to cerebrospinal fluid analysis in a naturalistic setting. METHODS This multicenter study was performed at French tertiary memory clinics in patients presenting with most comple...
متن کاملQualitative and quantitative assessment of self-reported cognitive difficulties in nondemented elders: Association with medical help seeking, cognitive deficits, and β-amyloid imaging
INTRODUCTION Subjective cognitive decline (SCD) could help identify early stages of Alzheimer's disease. However, SCD is multidetermined and protean, and the type of cognitive complaint associated with preclinical Alzheimer's disease needs refinement. METHODS A total of 185 nondemented elders recruited from either the community or from a memory clinic filled a questionnaire. We searched for i...
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